Research reference only. Research reference only. All compound descriptions are for educational and research purposes. Nothing here constitutes medical advice. Not intended for human use. Always consult a qualified healthcare professional.
What it is
MOTS-C is encoded within mitochondrial DNA itself, giving it a unique role as a retrograde mitochondrial signal. It activates AMPK pathway, the master regulator of cellular energy sensing. Research outcomes include improved insulin sensitivity, enhanced fatty acid utilisation, increased exercise capacity and VO2 efficiency, reduced fat mass, and improved glucose homeostasis. Pre-workout timing takes advantage of the metabolic demand window to maximise AMPK engagement. One of the more exciting longevity-adjacent compounds given its role in mitochondrial-nuclear communication.
Reconstitution & Dosing
| Parameter | Value |
|---|---|
| BAC water | 2ml |
| Each injection | 10iu |
| mg per injection | 2mg |
| When | Daily morning or pre-workout (training days preferred). |
| Duration | 2-3 months — then take a break |
AMPKInsulin SensitivityEnergyVO2Longevity